Bryan Johnson, a biohacker determined to extend his life as much as possible, has shared what he calls the most effective anti-aging method he’s tried so far.

The 47-year-old entrepreneur, who spends about $2 million a year on longevity treatments, once made headlines for receiving blood plasma from his teenage son in an effort to slow aging. Now, he’s turning to a different approach: hyperbaric oxygen therapy (HBOT).

In a recent YouTube video, Johnson showed off his high-pressure oxygen chamber, explaining how it works. “This saturates my body with 100% oxygen under high pressure,” he said.

“It accelerates healing, rebuilds the microbiome, is good for brain health, and increases my vascularization across my entire body.”

The treatment, which he uses for 90 minutes at a time, has delivered surprising results. “After 90 days of this therapy, it has proven to be the most efficacious therapy I’ve done since starting this project,” Johnson said.

I am no longer injecting my son's blood.

I've upgraded to something else: total plasma exchange.

Steps:
1. Take out all blood from body
2. Separate plasma from blood
3. Replace plasma with 5% albumin & IVIG

Here's my bag of plasma. Who wants it?
🧵 pic.twitter.com/rUScTIDea6

— Bryan Johnson (@bryan_johnson) January 28, 2025

“It lengthened my telomeres, reduced senescent cells, eliminated systematic inflammation from my body, reduced a marker for Alzheimer’s, rebuilt my microbiome, and gave me dramatically improved skin health.”

Hn shared another extreme part of his anti-aging routine: daily shockwave therapy. The biohacker, who aims to live beyond 150, describes the treatment as “intense” and admits it’s painful—but insists it’s crucial for maintaining joint health.

Johnson starts the five-minute session about two hours after waking up, targeting his knees and elbows to keep them functional as he ages. “Joints are a major issue for people as they age,” he says. “In fact, they limit our ability to do the things we love. I’m doing with this therapy the first whole body proactive therapy.”

He undergoes the treatment three times a week, enduring 4,500 shock pulses per session. Though he acknowledges the discomfort, he believes it’s necessary. “It’s first in the world, and it has done wonders for my joints,” Johnson claims. “And even though it hurts like hell, that’s what you want. Seek out the pain.”

Despite his intense focus on longevity, Johnson insists he’s not spending all day on anti-aging routines. “Many people assume that I relax and spend all my day in longevity. That is only part of my responsibilities,” he said.

“I also run three businesses as well as being a full-time content creator.”

In another video, ‘My $16/Day Diet to Live to 200+’, Johnson claimed his biological aging rate has slowed to 0.64—meaning he ages just 7.6 months for every full calendar year.

Comparing his approach to software updates, he said, “When you build software, you build version one, and it moves to version two and version three, every version gets a little better because you remove the bad stuff and add more good stuff. I’ve done the same thing with my diet.”

While Johnson is convinced of the therapy’s benefits, its experimental nature raises questions. Since he’s one of the first to try it at this scale, the long-term effects remain uncertain—including whether the pain actually strengthens his joints or just tests his endurance.